DNA polymerase-IN-2 - Search Results

About 5 results found for searched term "DNA polymerase-IN-2" (0.126 seconds)

Cat.No.	Name	Target
M41459	DNA polymerase-IN-2	DNA/RNA Synthesis
	DNA polymerase-IN-2, a coumarin derivative, exhibits inhibitory activity against Taq DNA polymerase with IC50 of 48.25 μM , which can be used in value-added disease research.
M3892	BMH-21	DNA/RNA Synthesis
	BMH-21 is a first-in-class DNA intercalator that binds to high-frequency GC-rich sequences in ribosomal DNA genes and can effectively and rapidly inhibit the transcription of RNA polymerase I (Pol I), leading to degradation of the Pol I catalytic subunit RPA194 and non-phosphorylation of histone H2AX. H2AX is not phosphorylated.BMH-21 has broad and potent antitumor activity in NCI60 cancer cell line and inhibits tumor growth in vivo.
M21558	ART812	DNA/RNA Synthesis
	ART812 is an orally effective DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 had an IC50 value of 240 nM for cell-based microhomologous mediated end-junction (MMEJ).
M28131	Rifalazil	DNA/RNA Synthesis
	KRM-1648; ABI-1648
	Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml.
M42935	DNA polymerase-IN-4	Others
	DNA polymerase-IN-4, a coumarin derivative, has antiretroviral activity with IC50 value of 134.22 μM.